Ciltakabtagen autoleucel
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- Mezinárodní název (INN)
- Ciltacabtagenum autoleucelum
- Anglicky
- CILTACABTAGENE AUTOLEUCEL
Synonyma: AUTOLOGOUS PERIPHERAL BLOOD MONONUCLEAR CELL (PBMC)- DERIVED T LYMPHOCYTES TRANSDUCED EX VIVO WITH A NONREPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING TWO EPITOPES OF THE HUMAN B CELL MATURATION ANTIGEN (BCMA) UNDER THE CONTROL OF A HUMAN ELONGATION FACTOR 1 ALPHA (EF1ALPHA) PROMOTER. THE CODING SEQUENCE COMPRISES A HUMAN CD8 ALPHA SIGNAL PEPTIDE (CD8ALPHA SP), A BCMA TARGETING DOMAIN CONSISTING OF TWO VARIABLE HEAVY CHAIN-ONLY ANTIBODIES (VHH1 AND VHH2) TARGETING TWO DISTINCT BCMA EPITOPES, A HUMAN CD8 ALPHA HINGE AND TRANSMEMBRANE DOMAIN (CD8ALPHA HINGE + TM), A HUMAN CD137 CYTOPLASMIC DOMAIN (4-1BB) AND A HUMAN CD3 ZETA CYTOPLASMIC DOMAIN (CD3ZETA). THE VECTOR GENOME CONTAINS A CHIMERIC ROUS SARCOMA VIRUS (RSV)/TRUNCATED 5'LTR AND A SELF-INACTIVATING 3'LTR-SIN (U3). REC. INN LIST 84 · CILTACABTAGEN AUTOLEUCEL · CILTACABTAGENE AUTOLEUCEL · CILTACABTAGENUM AUTOLEUCELUM · CILTAKABTAGEN AUTOLEUCEL
- Carvykti 3,2 x10^6-1 x10^8 buněk Infuzní disperze na předpis