CILTACABTAGENUM AUTOLEUCELUM
Účinná látka · 1 přípravek na trhu
- Mezinárodní název
- CILTACABTAGENUM AUTOLEUCELUM
- Český název
- CILTAKABTAGEN AUTOLEUCEL
- Anglicky
- CILTACABTAGENE AUTOLEUCEL
Synonyma: AUTOLOGOUS PERIPHERAL BLOOD MONONUCLEAR CELL (PBMC)- DERIVED T LYMPHOCYTES TRANSDUCED EX VIVO WITH A NONREPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING TWO EPITOPES OF THE HUMAN B CELL MATURATION ANTIGEN (BCMA) UNDER THE CONTROL OF A HUMAN ELONGATION FACTOR 1 ALPHA (EF1ALPHA) PROMOTER. THE CODING SEQUENCE COMPRISES A HUMAN CD8 ALPHA SIGNAL PEPTIDE (CD8ALPHA SP), A BCMA TARGETING DOMAIN CONSISTING OF TWO VARIABLE HEAVY CHAIN-ONLY ANTIBODIES (VHH1 AND VHH2) TARGETING TWO DISTINCT BCMA EPITOPES, A HUMAN CD8 ALPHA HINGE AND TRANSMEMBRANE DOMAIN (CD8ALPHA HINGE + TM), A HUMAN CD137 CYTOPLASMIC DOMAIN (4-1BB) AND A HUMAN CD3 ZETA CYTOPLASMIC DOMAIN (CD3ZETA). THE VECTOR GENOME CONTAINS A CHIMERIC ROUS SARCOMA VIRUS (RSV)/TRUNCATED 5'LTR AND A SELF-INACTIVATING 3'LTR-SIN (U3). REC. INN LIST 84 · CILTACABTAGEN AUTOLEUCEL · CILTACABTAGENE AUTOLEUCEL · CILTACABTAGENUM AUTOLEUCELUM · CILTAKABTAGEN AUTOLEUCEL
- CARVYKTI 3,2X10^6-1X10^8BUNĚK Infuzní disperze na předpis