BREXUCABTAGENUM AUTOLEUCELUM
Účinná látka · 1 přípravek na trhu
- Mezinárodní název
- BREXUCABTAGENUM AUTOLEUCELUM
- Český název
- BREXUKABTAGEN AUTOLEUCEL
- Anglicky
- BREXUCABTAGENE AUTOLEUCEL
Synonyma: AUTOLOGOUS T CELLS OBTAINED FROM THE PERIPHERAL BLOOD OF PATIENTS WITH RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA, COLLECTED BY LEUKAPHERESIS, TRANSDUCED WITH A MURINE STEM CELL VIRUS-BASED RETROVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) UNDER THE CONTROL OF THE 5' LONG TERMINAL REPEAT (LTR) MURINE STEM CELL VIRUS PROMOTER, COMPRISING A SINGLE-CHAIN VARIABLE FRAGMENT DERIVED FROM THE MURINE ANTIBODY FMC63 TARGETING CD19 (B-LYMPHOCYTE ANTIGEN CD19), A CD28 SPACER, A CD28 TRANSMEMBRANE AND INTRACELLULAR COSTIMULATORY DOMAINS, AND A CD3ZETA INTRACELLULAR ACTIVATION DOMAIN. THE T CELLS ARE SELECTED WITH ANTI-CD4 AND ANTI-CD8 COATED PARTICLES, ACTIVATED WITH ANTI-CD3, AND ANTI-CD28 ANTIBODIES AND CULTURED IN MEDIA CONTAINING IL-2. THE CD4/CD8 ENRICHED T CELLS ARE PREDOMINANTLY CD3+ (MORE OR EQUAL TO 98%), ANTI-CD19.CAR (MORE OR EQUAL TO 24%), AND CONTAIN ON AVERAGE 0.1% NATURAL KILLER (NK) CELLS AND 0.5% OTHER CELLULAR IMPURITIES...; PROPOSED INN: LIST 125, REC. INN: LIST 87 · BREXUCABTAGENE AUTOLEUCEL · BREXUCABTAGENUM AUTOLEUCELUM · BREXUCABTAGÉN AUTOLEUCEL · BREXUKABTAGEN AUTOLEUCEL · BRÉXUCABTAGENE AUTOLEUCEL · KTE-X19
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